Driving under the influence of drugs or impairing medicines reduces fitness to drive[i] and increases crash risk. Drugs have a numbing, stimulating or mind-altering effect on the brain, or a combination of these effects, which impair traffic task performance. For drug use in traffic, we (unfortunately) have to rely on research dating back to 2011.

Driver fatigue is estimated to be a (contributing) factor in 15 to 20% of crashes, but estimates in individual studies vary widely. Drivers who are tired are less attentive and react less quickly and less adequately than drivers who are not tired. They also get irritated and frustrated more easily.

In the Netherlands, licence acquisition courses for category B (passenger cars) are concluded by a theoretical and a practical test. Driving lessons are not obligatory, but without them passing the practical test is virtually impossible. For practical reasons, the effectiveness of drivings tests and driver training is hard to assess in a scientific way. A few studies of the effectiveness of theory tests and practical driving tests are indeed available. These do, however, not show a marked relation between crash risk and driving test performance or driver training.

Moped and light-moped riders are at relatively high risk of being a crash casualty. Although there is a trend towards fewer deaths, in the Netherlands, the risk of being killed or seriously injured remains very large compared with other modes of transport. In the Netherlands, helmet use is mandatory for moped riders, but not for light-moped riders. In recent years we have seen a strong increase in the number of light mopeds (especially the scooter model is widely sold), whereas the number of mopeds has been decreasing slightly.

In 2015, 47 motorcyclists died in traffic in the Netherlands. After 2009, when their number was approximately 1,300, it has not been possible to reliably determine the number of serious road injuries due to poor registration. In the Netherlands 1,4 million people have a motorcycle licence, but as there are 656,000 registered motorcycles, less than half own a motorcycle. These motorcyclists travel an average 1,200 to 3,400 km per year, which means that most do not really build a routine.