Studies are reported using the rapid infusion of dilute ethanol to produce sleep in man. it was noted that the prior administration of large doses of Librium induce a state of resistance to the soporific effects of alcohol, as compared with Nembutal which has a synergistic action. Studies of blood levels show that this is not associated with a more rapid breakdown of the ethanol, but to increased tolerance of the brain to its action. Higher blood levels are required to produce sleep after Librium than in normal subjects.
Abstract