Does cetirizine belong to the new generation of antihistamines ? : an investigation into its acute and subchronic effects on highway driving, psychometric test performance and daytime sleepiness.

Author(s)
Volkerts, E.R. Willigenburg, A.P.P. van Laar, M.W. van & Maes, R.A.A.
Year
Abstract

Twenty-seven healthy male volunteers participated in a double-blind, five-way crossover designed comparison of the new, selective H1-receptor antagonist cetirizine (10 mg q.d.) and terfanadine (60 mg b.i.d. and 120 mg. q.d.) versus the older H1-receptor antagonist triprolidine (5 mg b.i.d.) and placebo. Medication was administred during four consecutive days. Subjects were tested on the 1st and 4th treatment day. On each test day subjects drove an instrumented vehicle over a 100 km highway circuit while attempting to maintain a constant speed (90 km/hr) and a steady lateral position within the right traffic lane.

Request publication

7 + 6 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Publication

Library number
931659 ST [electronic version only]
Source

Human Psychopharmacology Clinical & Experimental, Vol. 7 (1992), No. 4 (July/August), p. 227-238, 43 ref.

Our collection

This publication is one of our other publications, and part of our extensive collection of road safety literature, that also includes the SWOV publications.