The purpose of this study was to eliminate the central side-effects of astemizole, if any, on real driving behaviour and psychomotor performance in healthy volunteers after repeated dosage of the drug. It is concluded that subchronic use of astimizole in a dosage regimen 10 mg t.i.d. for seven days followed by 10 mg daily for three days has no detrimental effect on actual car driving and psychomotor performance in the tests.
Abstract