Higher doses of Terfenadine and Loratadine. Acute and subchronic effects on psychomotor and actual driving performance.

Author(s)
Riedel, W.J. Ramaekers, J.G. Uiterwijk, M. & O'Hanlon, J.F.
Year
Abstract

Higher doses of antihistamines are advocated, especially for the treatment of bronchial asthma. Higher doses of so- called "old" antihistamines present the problem of sedation, resulting in the patients' unfitness to drive a car. Fourteen male and ten female volunteers received four separate treatments consisting of multiple terfenadine 120 mg bid, loratadine 20 mg OD, triprolidine 5 mg bid and placebo doses, over four consecutive days. This was done double- blind, with a dummy placebo following the daily loratadine dose, according to a cross- over design.

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Publication

Library number
B 31603 [electronic version only] /83 / IRRD 841320
Source

Maastricht, University of Limburg, Institute for Drugs, Safety and Behaviour / Instituut voor Geneesmiddelen, Veiligheid en Gedrag, 1990, 70 p., 31 ref.; I.G.V.G. 90- 08.

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