Abstract
Based on a metaanalytical analysis of experimental studies combined with pharmacokinetic data we tried to correlate the time of worst human performance and the time of highest serum-concentration after oral application of several drugs. Critically discussed we can postulate - as a first result - that the dosage does not influence the time of highest concentration but the time of worst performance, and that for substances with short resorption times the maximum of performance decrements is situated after the maximum of concentration and vice versa.