Residual effects on actual car driving of evening dosing of chlorpheniramine 8 and 12 when used with terfenadine 60 mg in the morning.

Author(s)
Vermeeren, A. Ramaekers, J.G. Leeuwen, C.J. van & O'Hanlon, J.F.
Year
Abstract

The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests. (A)

Request publication

2 + 14 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Publication

Library number
990291 ST (In: ST 990287)
Source

In: Drugs and driving : supplement of Human Psychopharmacology: Clinical and Experimental, Vol. 13 (1998), No. 52 (November), S79-S86, 23 ref.

Our collection

This publication is one of our other publications, and part of our extensive collection of road safety literature, that also includes the SWOV publications.