Abstract
Studies on man-machine interaction frequently lack the results of chemico-toxicological investigations. This presentation is concerned with investigating methodological aspects in carrying out chemicotoxicological tests within the framework of studies on man-machine interaction, focusing attention on the following points: need for pharmacokinetic studies; timing and methods of collecting biological samples; types and quantities of biological samples; choice of analytical approach; correlation between analytical data and psychomotor performance; need for quality assurance; and optimization of cost-benefit ratio. (A)