Samenvatting
Studies are reported using the rapid infusion of dilute ethanol to produce sleep in man. it was noted that the prior administration of large doses of Librium induce a state of resistance to the soporific effects of alcohol, as compared with Nembutal which has a synergistic action. Studies of blood levels show that this is not associated with a more rapid breakdown of the ethanol, but to increased tolerance of the brain to its action. Higher blood levels are required to produce sleep after Librium than in normal subjects.