The correlation between drug serum concentration and intensity of side-effects, especially reduction of driving performance, is very important for the causality between medication and traffic accident. But these concentration-effect relationships are still unknown. The most publications contain no serum concentration analyses in combination with the psychomotor performance. Additionally the individual results are governed by the specific study design and the moment of sample extraction. There is no knowledge on the kind of concentration-effect relationship based on a great number of published experimental studies. With a research project, sponsored by the Federal Highway Research Institute (BASt), a data base on drugs and driving related performance could be installed. These data built up the foundation for an analysis of concentration-effect relationship. (A)
Samenvatting