Samenvatting
A GC-MS (gas chromatography-mass spectrometry) method for simultaneous determination of pholcodine, morphine, codeine, 6-acetylmorphine, dihydrocodeine and ethylmorphine in urine and blood is described. The method employs propionic anhydride in the presence of triethylamine to propionylate free hydroxyl groups of the opiates. Confirmation is achieved using gas chromatography/mass spectrometry in the electron impact mode.