Several studies have been conducted to examine the value of gamma-glutamyl-transpeptidase (GGT) enzyme activity as a biochemical marker for alcohol consumption, alcohol problems, and abstinence from alcohol. This paper reports a study designed to analyse data collected as part of the drinking driver programme in Alameda County, CA, USA. The study examined client files for 1990 and 1991 participants, who chose a programme requiring periodic GGT blood testing, rather than ingestion of antabuse, to maintain abstinence. GGT scores were analysed to address: (1) gender and age differences in distribution of GGT scores; and (2) changes in GGT scores over time. Younger offenders were found to be significantly less likely to have high GGT levels. Participants with high GGT scores in a first test had lower average GGT scores in a second test, then tended to have somewhat higher GGT scores in a third test. Some possible explanations are indicated for this latter, unexpected rise. The study reviewed here was a preliminary review of scores in a larger study designed to evaluate GGT testing. GGT scores alone do not seem to be an effective monitor of abstinence for those convicted of multiple DUI (driving under the influence of alcohol).
Samenvatting