Samenvatting
The interrelationship between impulsive head loading parameters and either the presence and/or severity of diffuse axonal damage has not been fully developed. In this investigation, an experimental model of diffuse axonal injury is used to explore the relationship between intracranial deformations and axonal injury patterns. Surrogate models of the miniature pig skull-brain structure were tested to develop emperical relationships for the regional brain tissue distortion occurring in response to an impulsive head rotation. The study represents a first approach towards merging biomechanical data with neuroanatomic information to relate the distribution and severity of axonal injury with specific macroscopic head motion parameters.